Dr. Amit Singh
Our research activities are aimed at understanding the fundamental mechanisms involved in chronic human infections. We are focusing our efforts on dissecting how redox signaling controls virulence properties of Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV).
Dr. Annapurna Vyakarnam
Immunilogy of HIV-Tuberculosis co-infection
My long-term research interests have focused on soluble factors / cytokines and their role in immunomodulation and immunity to infection, specifically defining CD4 T-cell subset function in the context of HIV pathogenesis. My laboratory uses a diverse set of methodologies covering immunology, cell biology and molecular biology and genomics to probe CD4 T-cell function at the cell and molecular level. Current areas of interest include, HIV-host interactions to define novel host factors in CD4 T cells that regulate HIV infection and to understand how CD4 T cell dysregulation in HIV infection can specifically contribute to the reactivation of latent TB in HIV-infected subjects. The laboratory hopes that basic knowledge gained from such studies can be translated to new biomarkers of disease and identify host pathways that may serve as novel therapeutic targets in HIV and TB infections.
Our lab is interested in studying host-interactions of emerging human viruses, especially Influenza and Flaviviruses (Zika, Dengue), to understand the molecular basis of viral pathogenesis. For this we use Omics approaches (genomewide CRISPR screens, protein-protein interactome and Virus-Host Big Data analysis) in combination with conventional virology, reverse genetics, small animal models and molecular-cell biology methods. We are also working towards development of novel influenza vaccines which provide broad and long term protection. Also, we are exploring novel mechanisms of antiviral innate immunity, which can be leveraged to develop broad spectrum antivirotics and improve vaccine efficacy.