Our lab is interested in studying host-interactions of emerging human viruses, especially Influenza and Flaviviruses (Zika, Dengue), to understand the molecular basis of viral pathogenesis. For this we use Omics approaches (genomewide CRISPR screens, protein-protein interactome and Virus-Host Big Data analysis) in combination with conventional virology, reverse genetics, small animal models and molecular-cell biology methods. We are also working towards development of novel influenza vaccines which provide broad and long term protection. Also, we are exploring novel mechanisms of antiviral innate immunity, which can be leveraged to develop broad spectrum antivirotics and improve vaccine efficacy.