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Viral Biosafety Level – 3 (Viral BSL-3) Laboratory

The Viral Biosafety level three facility (BSL-3) has been established in the Centre for Infectious Disease Research (CIDR) Building, IISc Campus, Bangalore for conducting research on BSL3 category viral pathogens such as SARS-CoV-2. It consists of one BSL3 lab for cell-based experiments and one infection-cum-necropsy room for animal experiments. There are appropriate change rooms, an autoclave room, and a plant room. This lab has special safety and engineering features for maintaining requisite negative pressure environment to ensure unidirectional airflow, and for ensuring safety of lab personnel. Go through the SOPs to understand the prerequisites for accessing the facility.

We undertake consultancy research projects​ related to vaccine or anti-viral studies. For further details contact at shashankt@iisc.ac.in

Below are the list of consultancy projects handled so far.

VACCINE STUDIES

SL No.

Company

Aim of the study

1

GLYCOVAX PHARMACANADA

Evaluating efficacy of a glycoconjugate vaccine candidate against SARS-CoV-2 

2

GENNOVA BIOPHARMACEUTICALS LTD., INDIA 

Evaluating efficacy of a mRNA based Covid-19 vaccine candidate  (GEMCOVAC-19)

3

PREMAS BIOTECH PVT LTD., INDIA

Evaluating efficacy of a Virus like particle vaccine candidate against SARS-CoV-2

4

CSIR-IMTECH, INDIA

To test efficacy of a subunit vaccine against SARS-CoV-2 virus

5

CSIR-CCMB

Evaluating efficacy of a mRNA based Covid-19 vaccine candidate

6

BARC, INDIA

Evaluating efficacy of a Liposomal Spike vaccine candidate against SARS-CoV-2

ANTIVIRAL STUDIES

SL No.

Company

Aim of the study

1

GENEXT GENOMICS PVT LTD

Evaluating efficacy of an anti-SARS-CoV-2 ScFVs in Spike pseudotyped entry assay

2

BIOMONETA RESEARCH PVT. LTD., INDIA

Evaluating efficacy of ZeBox in eliminating airborne influenza and SARS-CoV-2 viruses.

3

KASHIV BIOSCIENCES, USA

To test in vitro antiviral efficacy of new synthetic chemical entities against SARS-CoV-2 in cell culture system

4

SHARP BUSINESS SYSTEMS, INDIA

To test for the in vitro anti SARS-CoV-2 activity of TUNGSTEN TRIOXIDE-COATED PLATES  and NATURIZER (disinfectant) solution

5

CSIR-CIMAP, INDIA

To test the anti-SARS-CoV-2 activity of different herbal formulations through oral administration.

SERVICES PROVIDED

Vaccine testing in animal model and the antiviral studies in cell culture.​

  • RT-PCR: SARS-CoV-2 Viral load (Lungs, nasal turbinates, nasal wash etc.) , Pro and anti-inflammatory cytokines level.
  • ELISA: SARS-CoV-2 RBD specific antibodies, cytokines level.
  • Histology: Lungs, spleen, liver, nasal turbinates etc.
  • Neutralization assays: Live virus and Psuedovirus based assays
  • Other parameters studies: Body weight, clinical signs, organ’s gross morphology.
  • Cytotoxicity and antiviral assays: In VERO and HEK 293T cells etc.

SARS-CoV-2 virus variants available for studies:
Wuhan, Alpha, Beta, Gamma, Delta, Omicron.

NEWS​​

 

Dr. Shashank Tripathi
Faculty Incharge
VIRAL Biosafety Level-3 Laboratory
Centre for Infectious Disease Research (CIDR)
MCB Department
Indian Institute of Science
CV Raman Avenue
Bangalore-560012
India
080-2292884/3063

 

Dr. Rohan Narayan
Incharge
VIRAL Biosafety Level-3 Laboratory
Centre for Infectious Disease Research (CIDR)
Indian Institute of Science
CV Raman Avenue
Bangalore-560012
India
080-2292884/3063