List of Publications

Publication in 2024

  1. Prabhakar S, Lin QXX, Rajagopalan D, Gamage AM, Le Tan M, Venkatesh P, Chan WOY, Dilip Kumar, Agrawal R, Chen Y, Fong SW, Singh A, Sun JL, Tan SY, Chai L, Somani J, Lee B, Laurent Renia, Lisa Ng, Kollengode Ramanathan, Lin-Fa Wang, Barnaby E Young, David Lye, and SinghalA. Longitudinal Single Cell Atlas Identifies Complex Temporal Relationship between Type I Interferon Response and COVID-19 Severity. Nat Commun. 2024. 15: 567
  2. Kumar N, Santhoshkumar R, Agrawal R, Singh A, Kalyan V, Desai A, Ravi V, Venkataswamy MM. Neuropathogenesis of SARS-CoV-2 in human neuronal, microglial and glial cells. Arch Microbiol. 2024. 206(8): 345
  3. Manna S, Agrawal R, Yadav T, Kumar TA, Kumari P, Dalai A, Kanade S, Balasubramanian N, Singh A, Chakrapani H. Orthogonal Persulfide Generation through Precision Tools Provides Insights into Mitochondrial Sulfane Sulfur. Angew Chem Int Ed Engl. 2024. 2: e202411133
  4. Dewan A, Jain C, Das M, Tripathi A, Sharma AK, Singh H, Malhotra N, Seshasayee ASN, Chakrapani H, Singh A. Intracellular peroxynitrite perturbs redox balance, bioenergetics, and Fe-S cluster homeostasis in Mycobacterium tuberculosis. Redox Biol. 2024. 75: 103285

Publications in 2023

  1. Shyam M, Bhattacharje G, Daniel C, Kumar A, Yadav P, Mukherjee P, Singh S, Das AK, Narender T, Singh A, et al. Rationally Designed Novel Phenyloxazoline Synthase Inhibitors: Chemical Synthesis and Biological Evaluation to Accelerate the Discovery of New Antimycobacterial Antibiotics.Molecules. 28(24): 8115
  2. Das M, Sreedharan S, Shee S, Malhotra N, Nandy M, Banerjeee U, Kholi S, Rajmani R, Chandra N, Seshasayee AN, Laxman S and Singh A. Cysteine desulfurase (IscS)–mediated fine- tuning of bioenergetics and SUF expression prevents Mycobacterium tuberculosis Sci Adv. 2023. 15(50): eadh2858
  3. Banerjee U, Chunchanur S, R A, Balaji KN, Singh A, Chakravortty D and Chandra N. Systems-level profiling of early peripheral host-response landscape variations across COVID-19 severity states in an Indian cohort. Genes Immun. 2023. 24(4): 183-193
  4. Singh PR, Dadireddy V, Udupa S, Kalladi SM, Shee S, Khosla S, Rajmani RS, Singh A, Ramakumar S, Nagaraja V. The Mycobacterium tuberculosis methyltransferase Rv2067c manipulates host epigenetic programming to promote its own survival. Nat Commun. 14(1): 8497
  5. Banerjee U, Chedere A, Padaki R, Mohan A, Sambaturu N, Singh A and Chandra N. PathTracer Comprehensively Identifies Hypoxia-Induced Dormancy Adaptations inMycobacterium tuberculosis. J Chem Inf Model. 2023. 63(19): 6156-6167
  6. Shee S, Veetil RT, Mohanraj K, Das M, Malhotra N, Bandopadhyay D, Beig H, Birua S, Niphadkar S, Nagarajan SN, Sinha VK, Thakur C, Rajmani RS, Chandra N, Laxman S, Singh M, Samal A, Seshasayee AN and Singh A. Biosensor-integrated transposon mutagenesis revealsrv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis. eLife. 2023. 29:12. e80218
  7. Dey A, Anand K, Singh A, Prasad R and Barthwal R.MOSR and NDHA Genes Comprising G-Quadruplex as Promising Therapeutic Targets against Mycobacterium tuberculosis: Molecular Recognition by Mitoxantrone Suppresses Replication and Gene Regulation. Genes. 2023. 14: 978
  8. Subhadra B, Agrawal R, Pal VK, Chenine AL, Mattathi JG and Singh, A. Significant Broad-Spectrum Antiviral Activity of Bi121 against Different Variants of SARS-CoV-2. Viruses, 15(6), 2023. 15(6): 1299

Publications in 2022

  1. Shee S, Singh S, Tripathi A, Thakur C, Kumar T A, Das M, Yadav V, Kohli S, Rajmani RS, Chandra N, Chakrapani H, Drlica K and Singh A. Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species. Antimicrob Agents Chemother. 2022. 20: e0059222
  2. Bandyopadhyay P, Pramanick I, Biswas R, Sabarinath PS, Sreedharan S, Singh S, Rajmani R, Laxman S, Dutta S and Singh A. S-Adenosylmethionine-responsive cystathionine b-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis. Sci Adv. 2022. 8: eabo0097
  3. Tripathi A, Anand K, Das M, O’Niel RA, Sabarinath PS, Thakur C, Reddy RRL, Rajmani R, Chandra N, Laxman S and Singh A. Mycobacterium tuberculosis requires SufT for Fe-S cluster maturation, metabolism, and survival in vivo. PLoS Pathog. 2022. 18(4): e1010475
  4. Singh A, Zhao and Drlica K. Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement. Front Cell Infect Microbiol. 2022. 29: 1165
  5. Raja S, Paul A, Raghavan S, Narayanan S, Shee S, Singh A, Varshney U, Gopal B and Vijayan.
    Structural Variability of Mycobacterium tuberculosis SSC and susceptibility to inhibition. Current Sci. 2022. 122: 281
  6. Prathiar S, Agrawal R, Pal VK, Singh A and Govindaraju T. Reliable fluorometric detection of SARS-CoV2 by targeting the G-Quadruplex through pH- triggered conformational polymorphism. ACS Sens. 2022. 7: 453 – 459
  7. Thakur C, Tripathi A, Ravichandran S, Shivananjaiah A, Chakraborty A, Vardappa S, Chikkanvenkatappa N, Nagaraja D, Lakshminarasimhaiah S, Singh A, Chandra N. A new blood-based RNA signature (R9), for monitoring effectiveness of tuberculosis treatment in a South Indian longitudinal cohort. iScience. 2022. 103745
  8. Shyam M, Verma H, Bhattacharje G, Mukherjee P, Singh S, Kamilya S, Jalani P, Das S, Dasgupta A, Mondal A, Das AK, Singh A, Brucoli F, Bagnéris C, Dickman R, Basavanakatti VN, Naresh Babu P, Sankaran V, Dev A, Sinha BN, Bhakta S, Jayaprakash V. Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition. J Med Chem. 2022. 65: 234-256
  9. Banerjee U, Rao P, Reddy M, Hussain M, Chunchanur S, Ambica R, Singh A and Chandra N. A 9-gene biomarker panel identifies bacterial coinfections in culture-negative COVID-19 cases. Mol Omics. 2022. 18: 814 – 820

Publications in 2021

  1. Pal VK, Agrawal R, Rakshit S, Shekar P, Murthy DTN, Vyakarnam A and Singh A. Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox Homeostasis. eLife. 2021. e68487
  2. Shytaj IL, Procopio AF, Tarek M, Carlon-Andres I, Tang HY, Goldman AR, Munshi MH, Pal VK, Forcato M, Sreeram S, Leskov K, Ye F, Lucic B, Cruz N, Ndhlovu LS, Bicciato S, Padilla-Parra S, Diaz RS, Singh A, Lusic M, Karn, Alvarez-Carbonell D and Savarino A. Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress. EMBO Mol Med. e13901
  3. Biji A, Khatun O, Swaraj S, Narayan R, Rajmani R, Sardae R, Satish D, Mehta S, Bindhu H, Jeevan M, Saini D, Singh A, Gupta D and Tripathi S. Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples. EBioM. 2021. 70: 103525
  4. Anand K, Tripathi A, Shukla K, Malhotra N, Jamithireddy AK, Jha RK, Chaudhury SN, Rajmani RS, Ramesh A, Nagaraja V, Gopal B, Nagaraju G, Seshasayee ASN and Singh A. Mycobacterium tuberculosis SufR Responds to Nitric oxide via its 4Fe-4S cluster and Regulates Fe-S cluster Biogenesis for Persistence in Mice. Redox Biol. 2021. 102062
  5. Ravichandran S, Banerjee U, Devi GDR, Kandukuru R, Thakur C, Chakravortty D, Balaji KN, Singh A and Chandra N. VB10, a new blood biomarker for differential diagnosis and recovery monitoring of acute viral and bacterial infections. EBioM. 2021. 67: 103352
  6. Das M, Dewan A, Shee S and Singh A. The Multifaceted Bacterial Cysteine Desulfurases: From Metabolism to Pathogenesis. Antioxidants. 2021. 10: 997
  7. Banerjee U, Baloni P, Singh A and Chandra N. Immune Subtyping in Latent Tuberculosis. Front Immunol. 2021. 12: 595746.
  8. Nukathoti S, Nikitha H, Singh S, Singh A, Mamannamana V and Surolia A. Mevo lectin specificity towards high-mannose structures with terminal αMan(1,2)αMan residues and its implication to inhibition of the entry of Mycobacterium tuberculosis into macrophages. Glycobiology. 2021. cwab022
  9. Singh S, Ghosh S, Pal VK, Munshi MH, Shekhar P, Murthy DTN, Mugesh G and Singh A. Antioxidant nanozyme counteracts HIV-1 by modulating intracellular redox potential. EMBO Mol Med. e13314

Publications in 2020

  1. Mishra R, Yadav V, Guha M and Singh A. Heterogeneous Host–Pathogen Encounters Coordinate Antibiotic Resilience inMycobacterium tuberculosis. Trends Microbiol. 2020. S0946-842
  2. Banerjee U, Sankar S, Singh A and Chandra N. A Multi-pronged computational pipeline for prioritizing drug target strategies for latent tuberculosis. Front Chem. 2020. 8: 593497
  3. Bhaskar A, Kumar S, Khan MZ, Singh A, Dwivedi VP and Nandicoori VK. Host sirtuin 2 as an immunotherapeutic target against tuberculosis. eLife. 2020. 9: e55415
  4. Sachdeva K, Goel M, Sudhakar M, Mehta M, Raju R, Raman K, Singh A and Sundaramurthy V. Mycobacterium tuberculosis (Mtb) lipid-mediated lysomal rewiring in infected macrophages modulates intracellular Mtb trafficking and survival. J Bio Chem. 2020. RA120: 012809
  5. Tyagi P, Pal VK, Agrawal R, Srinivasan S, Singh, S and Singh A. Mycobacterium tuberculosisreactivates HIV-1 via exosomes-mediated resetting of cellular redox potential and bioenergetics. 2020. 11: e03293

 

Publications in 2019

  1. Mishra R, Kohli S, Malhotra N, Bandyopadhyay P, Mehta M, Munshi M, Adiga V, Ahuja VK, Shandil RK, Rajmani RS, Seshasayee ASN and Singh A. Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis. Sci Transl Med. 11: eaaw6635
  2. Sutar YB, Mali JK, Telvekar VN, Rajmani RS and Singh A. Transferrin conjugates of antitubercular drug isoniazid: Synthesis and in vitro efficacy. Eur J Med Chem. 2019. 183:111713
  3. Verma T, Podder S, Mehta M, Singh S and Singh A, Umapathy S and Nandi D. Raman spectroscopy reveals distinct differences between two closely related bacterial strains, Mycobacterium indicus pranii and Mycobacterium intracellulare. Anal Bioanal Chem. 2019. 411: 7997–8009

Publications in 2018

  1. Mehta M, Agarwal N and Singh A. Mycobacterium tuberculosis WhiB3 maintains redox homeostasis and survival in response to reactive oxygen and nitrogen species. Free Radic Biol Med. 2018. 27(131): 50-58
  2. Mahadik K, Prakhar P, Rajmani RS, Singh A and Balaji KN. c-Abl-TWIST1 Epigenetically Dysregulate Inflammatory Responses during Mycobacterial Infection by Co-Regulating Bone Morphogenesis Protein and miR27a. Front Immunol. 2018.  1(9): 85
  3. Singh A and Surolia A. Tuberculosis: Today’s researches-tomorrow’s therapies. IUBMB Life. 2018. 70(9): 814-817
  4. Libardo MDJ, de la Fuente-Nuñez C, Anand K, Krishnamoorthy G, Kaiser P, Pringle SC, Dietz C, Pierce S, Smith MB, Barczak A, Kaufmann SHE, Singh A and Angeles-Boza AM. Phagosomal Copper-Promoted Oxidative Attack on Intracellular Mycobacterium tuberculosis. ACS Infect Dis. 2018. 4(11): 1623 – 1634
  5. Chawla M, Mishra S, Anand K, Parikh P, Mehta M, Vij M, Verma T, Singh P, Jakkala K, Verma HN, AjitKumar P, Ganguli M, Narain Seshasayee AS and Singh A. Redox-dependent condensation of the mycobacterial nucleoid by WhiB4. Redox Biol. 2018. 13(19): 116-133
  6. Sikri K, Duggal P, Kumar C, Batra SD, Vashist A, Bhaskar A, Tripathi K, Sethi T, Singh A and Tyagi JS. Multifaceted remodeling by vitamin C boosts sensitivity of Mycobacterium tuberculosis subpopulations to combination treatment by anti-tubercular drugs. Redox Biol. 2018. 15: 452-466
  7. Pal VK, Bandyopadhyay P and Singh A. Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses. IUBMB Life. 2018. 70 (5): 393-410.

Publications in 2017

  1. Mishra S, Shukla P, Bhaskar A, Anand K, Baloni P, Jha RK, Mohan A, Rajmani RS, Nagaraja V, Chandra N and Singh A. Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis. eLife. 2017. 26(6): e25624
  2. Khan MZ, Bhaskar A, Upadhyay S, Kumari P, Rajmani RS, Jain P, Singh A, Kumar D, Bhavesh NS and Nandicoori VK. Protein kinase G confers survival advantage to Mycobacterium tuberculosis during latency-like conditions. J Biol Chem. 2017. 292(39): 16093-16108
  3. Shukla P, Khodade VS, SharathChandra M, Chauhan P, Mishra S, Siddaramappa S, Pradeep BE, Singh A and Chakrapani H. “On demand” redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor. Chem Sci. 2017. 8(7): 4967-4972
  4. Sambarey A, Devaprasad A, Baloni P, Mishra M, Mohan A, Tyagi P, Singh A, Akshata JS, Sultana R, Buggi S and Chandra N. Meta-analysis of host response networks identifies a common core in tuberculosis. NPJ Syst Biol Appl. 2017. 10(3): 4

Publications in 2016

  1. Padiadpu J, Baloni P, Anand K, Munshi M, Thakur C, Mohan A, Singh A and Chandra N. Identifying and Tackling Emergent Vulnerability in Drug-Resistant Mycobacteria. ACS Infect Dis. 2016. 2(9): 592-607
  2. Holla S, Prakhar P, Singh V, Karnam A, Mukherjee T, Mahadik K, Parikh P, Singh A, Rajmani RS, Ramachandra SG and Balaji KN. MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection. PLoS Pathog. 2016. 12(8): e1005814
  3. Palmer CS, Henstridge DC, Yu D, Singh A, Balderson B, Duette G, Cherry CL, Anzinger JJ, Ostrowski M and Crowe SM. Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure. J Immunol. 2016. 196(11): 4437-44
  4. Palmer CS, Cherry CL, Sada-Ovalle I, Singh A and Crowe SM. Glucose Metabolism in T Cells and Monocytes: New Perspectives in HIV Pathogenesis. EBioMedicine. 2016. 6: 31-41
  5. Mehta M, Rajmani RS and Singh A. Mycobacterium tuberculosis WhiB3 Responds to Vacuolar pH-induced Changes in Mycothiol Redox Potential to Modulate Phagosomal Maturation and Virulence. J Biol Chem. 2016. 291(6): 2888-903
  6. Palde PB, Bhaskar A, Pedró Rosa LE, Madoux F, Chase P, Gupta V, Spicer T, Scampavia L, Singh A and Carroll KS. First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating tuberculosis. ACS Chem Biol. 2016. 11(1): 172-84

Publications in 2015

  1. Anand A, Verma P, Singh AK, Kaushik S, Pandey R, Shi C, Kaur H, Chawla M, Elechalawar CK, Kumar D, Yang Y, Bhavesh NS, Banerjee R, Dash D, Singh A, Natarajan VT, Ojha AK, Aldrich CC and Gokhale RS. Polyketide Quinones Are Alternate Intermediate Electron Carriers during Mycobacterial Respiration in Oxygen-Deficient Niches. Mol Cell. 2015. 60(4): 637-50
  2. Chandra P, Ghanwat S, Matta SK, Yadav SS, Mehta M, Siddiqui Z, Singh A and Kumar D. Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages. Sci Rep. 2015. 5: 16320
  3. Sharma S, Rajmani RS, Kumar A, Bhaskar A, Singh A, Manivel V, Tyagi AK and Rao KV. Differential proteomics approach to identify putative protective antigens of Mycobacterium tuberculosis presented during early stages of macrophage infection and their evaluation as DNA vaccines. Indian J Exp Biol. 2015. 53(7): 429-39
  4. Tyagi P, Dharmaraja AT, Bhaskar A, Chakrapani H and Singh A. Mycobacterium tuberculosis has diminished capacity to counteract redox stress induced by elevated levels of endogenous superoxide. Free Radic Biol Med. 2015. 84: 344-354
  5. Kumar S, Vendruscolo M, Singh A, Kumar D and Samal A. Analysis of the hierarchical structure of the subtilis transcriptional regulatory network. Mol Biosyst. 2015. 11(3): 930-41
  6. Bhaskar A, Munshi M, Khan SZ, Fatima S, Arya R, Jameel S and Singh A. Measuring glutathione redox potential of HIV-1-infected macrophages. J Biol Chem. 2015. 290(2): 1020-38

Publications in 2011 – 2014

  1. Bhaskar A, Chawla M, Mehta M, Parikh P, Chandra P, Bhave D, Kumar D, Carroll KS and Singh A. Reengineering redox sensitive GFP to measure mycothiol redox potential of Mycobacterium tuberculosis during infection. PLoS Pathog. 2014. 10(1): e1003902
  2. Chawla M, Parikh P, Saxena A, Munshi M, Mehta M, Mai D, Srivastava AK, Narasimhulu KV, Redding KE, Vashi N, Kumar D, Steyn AJ and Singh A. Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo. Mol Microbiol. 2012. 85(6): 1148-65
  3. Karim AF, Chandra P, Chopra A, Siddiqui Z, Bhaskar A, Singh A and Kumar D. Express path analysis identifies a tyrosine kinase Src-centric network regulating divergent host responses to Mycobacterium tuberculosis J Biol Chem. 2011. 286(46): 40307-19

Publications as a Post-Doctoral Fellow

  1. Farhana A, Guidry L, Srivastava A, Singh A, Hondalus MK and Steyn AJ. Reductive stress in microbes: implications for understanding Mycobacterium tuberculosis disease and persistence. Adv Microb Physiol. 2010. (57): 43-117
  2. Singh A, Crossman DK, Mai D, Guidry L, Voskuil MI, Renfrow MB and Steyn AJ. Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response. PLoS Pathog. 2009. 5(8):e1000545
  3. Singh A, Guidry L, Narasimhulu KV, Mai D, Trombley J, Redding KE, Giles GI, Lancaster JR Jr and Steyn AJ. Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival. Proc Natl Acad Sci USA. 2007.104(28): 11562-7
  4. Singh A, Mai D, Kumar A and Steyn AJ. Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association. Proc Natl Acad Sci USA. 2006. 103(30): 11346-51.

Publications as a Doctoral Fellow

  1. Singh R, Singh A and Tyagi AK. Deciphering the genes involved in pathogenesis of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2005. 85(5-6): 325-35
  2. Singh A, Gupta R, Vishwakarma RA, Narayanan PR, Paramasivan CN, Ramanathan VD and Tyagi AK. Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs. J Bacteriol. 2005. 187(12): 4173-86
  3. Deol P, Vohra R, Saini AK, Singh A, Chandra H, Chopra P, Das TK, Tyagi AK and Singh Y. Role of Mycobacterium tuberculosis Ser/Thr kinase PknF: implications in glucose transport and cell division. J Bacteriol. 2005. 187(10): 3415-20
  4. Singh R, Rao V, Shakila H, Gupta R, Khera A, Dhar N, Singh A, Koul A, Singh Y, Naseema M, Narayanan PR, Paramasivan CN, Ramanathan VD and Tyagi AK. Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs. Mol Microbiol. 2003. 50(3): 751-62
  5. Singh A, Jain S, Gupta S, Das T and Tyagi AK. mymA operon of Mycobacterium tuberculosis: its regulation and importance in the cell envelope. FEMS Microbiol Lett. 2003. 227(1): 53-63