e-mail

office.cidr@iisc.ac.in

Publication

2024:

  1. “Scalable bioprocess for the high-yield production of SARS-CoV-2 trimeric spike protein-based immunogen (IMT-CVAX) using suspension CHO cells.” Sneha Singh, B. Vikram Kumar, Jitender, a, Pranaya M. Mishra, Geetika Verma, Suvechchha Pandit, Sahil Kumar, Reetesh Kumar, Rajesh P. Ringe, Shashank Tripathi, Nimesh Gupta and Ravi P.N. Mishra. Process Biochemistry 147, 332-346 https://doi.org/10.1016/j.procbio.2024.08.022
  1. “Mammalian cell expressed recombinant trimeric spike protein is a potent vaccine antigen and confers near-complete protection against SARS-CoV-2 infection in Hamster.” B Vikram Kumar, Sneha Singh, Geetika Verma, Reetesh Kumar, Pranaya M Mishra, Sahil Kumar, Santhosh K Nagaraj, Joydeep  Nag, Christy M Joy, Bhushan Nikam, Dharmendra Singh, Nidhi Kalidas, Shubham Singh, Ashwani K Bhardwaj, Dhananjay S     Mankotia, Rajesh P Ringe, Nimesh Gupta, Shashank Tripathi, Ravi PN Mishra. Vaccine 42 (20), 126099. (Research article) https://doi.org/10.1016/j.vaccine.2024.06.066
  2.  Interference without interferon: interferon-independent induction of interferon-stimulated genes and its role in cellular innate immunity S Swaraj, S Tripathi mBio, e02582-24 https://doi.org/10.1128/mbio.02582-24

2023:

  1. Mucosal SARS-CoV-2 vaccination of rodents elicits superior systemic T central memory function and cross-neutralising antibodies against variants of concern.Aled O’Neill, Chinmay Kumar Mantri, Chee Wah Tan, Wilfried AA Saron, Santhosh Kambaiah Nagaraj, Monica Palanichamy Kala, Christy Margarat Joy, Abhay PS Rathore, Shashank Tripathi, Lin-Fa Wang, Ashley L St John. Ebiomedicine 99.https://doi.org/10.1016/j.ebiom.2023.104924
  2. SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
    O Khatun, M Sharma, R Narayan, S Tripathi. Cellular and Molecular Life Sciences 80 (12), 364.https://doi.org/10.1007/s00018-023-05011-3
  3. Picolinic acid is a broad-spectrum inhibitor of enveloped virus entry that restricts SARS-CoV-2 and influenza A virus in vivo. Rohan Narayan, Mansi Sharma, Rajesh Yadav, Abhijith Biji, Oyahida Khatun, Sumandeep Kaur, Aditi Kanojia, Christy Margrat Joy, Raju Rajmani, Pallavi Raj Sharma, Sharumathi Jeyasankar, Priya Rani, Radha Krishan Shandil, Shridhar Narayanan, Durga Chilakalapudi Rao, Vijaya Satchidanandam, Saumitra Das, Rachit Agarwal, Shashank Tripathi. Cell Reports Medicine, 15 August 2023 | DOI: https://doi.org/10.1016/j.xcrm.2023.101127
  4. A broadly protective CHO cell expressed recombinant spike protein subunit based vaccine (IMT-CVAX) against SARS-CoV-2.Bhusarapu Vikram Kumar, Sneha Singh, Geetika Verma, Reetesh Kumar, Pranaya M Mishra, Sahil Kumar, Santhosh K Nagaraj, Joydeep Nag, Christy M Joy, Bhushan Nikam, Dharmendra Singh, Nidhi Kalidas, Shubham Singh, Ashwani K Bhardwaj, Dhananjay S Mankotia, Rajesh P Ringe, Nimesh Gupta, Shashank Tripathi, Ravi PN Mishra.bioRxiv, 4th April 2023 | DOI: https://doi.org/10.1101/2023.04.03.534161
  5. Human antigen R differentially modulates the translation of SARS-CoV-2 genomic and sub-genomic RNAs, Harsha Raheja, Risabh Sahu, Trinath Ghosh, Priya Rani, Biju George, Shashank Tripathi, Saumitra Das.bioRxiv,16th March 2023 | DOI: https://doi.org/10.1101/2023.03.15.532790
  6. Enhanced recombination among Omicron subvariants of SARS‐CoV‐2 contributes to viral immune escape.Rishad Shiraz, Shashank Tripathi.Medical Virology,24th Jan 2023 | DOI: https://doi.org/10.1002/jmv.28519
  7. Ubiquitin-Mediated Regulation of Autophagy During Viral Infection.Joydeep Nag, Janvi Patel, Shashank Tripathi. Current Clinical Microbiology Reports, 13 January 2023 | DOI: https://doi.org/10.1007/s40588-022-00186-y
  8. Human antigen R differentially modulates the translation of SARS-CoV-2 genomic and sub-genomic RNAs, Harsha Raheja, Risabh Sahu, Trinath Ghosh, Priya Rani, Biju George, Shashank Tripathi, Saumitra Das.bioRxiv,16th March 2023 | DOI: https://doi.org/10.1101/2023.03.15.532790
  9. A broadly protective CHO cell expressed recombinant spike protein subunit based vaccine (IMT-CVAX) against SARS-CoV-2.Bhusarapu Vikram Kumar, Sneha Singh, Geetika Verma, Reetesh Kumar, Pranaya M Mishra, Sahil Kumar, Santhosh K Nagaraj, Joydeep Nag, Christy M Joy, Bhushan Nikam, Dharmendra Singh, Nidhi Kalidas, Shubham Singh, Ashwani K Bhardwaj, Dhananjay S Mankotia, Rajesh P Ringe, Nimesh Gupta, Shashank Tripathi, Ravi PN Mishra.bioRxiv, 4th April 2023 | DOI: https://doi.org/10.1101/2023.04.03.534161
  10. Ubiquitin-Mediated Regulation of Autophagy During Viral Infection.Joydeep Nag, Janvi Patel, Shashank Tripathi.bioRxiv 13th Jan 2023. | DOI: https://doi.org/10.1101/2023.04.03.534161
  11. Enhanced recombination among Omicron subvariants of SARS‐CoV‐2 contributes to viral immune escape.Rishad Shiraz, Shashank Tripathi.Medical Virology, 24th Jan 2023 | DOI: https://doi.org/10.1002/jmv.28519

 

2022:

  1. Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans. Christian V Forst, Laura Martin-Sancho, Shashank Tripathi, Guojun Wang, Luiz Gustavo Dos Anjos Borges, Minghui Wang, Adam Geber, Lauren Lashua, Tao Ding, Xianxiao Zhou, Chalise E Carter, Giorgi Metreveli, Ariel Rodriguez-Frandsen, Matthew D Urbanowski, Kris M White, David A Stein, Hong Moulton, Sumit K Chanda, Lars Pache, Megan L Shaw, Ted M Ross, Elodie Ghedin, Adolfo García-Sastre, Bin Zhang. Science Advances, 5th October 2022 | DOI : https://doi.org/10.1126/sciadv.abm5859

  2. Flavivirus–Host Interaction Landscape Visualized through Genome-Wide CRISPR Screens. Aditi Kanojia, Mansi Sharma, Rishad Shiraz, Shashank Tripathi. Viruses, 25th September 2022 | DOI : https://doi.org/10.3390/v14102164

  3. Enhanced Recombination Among SARS-CoV-2 Omicron Variants Contribute To Viral Immune Escape. Rishad Shiraz, Shashank Tripathi. bioRxiv, 24th August 2022 | DOI : https://doi.org/10.1101/2022.08.23.504936

  4. Efficient Elimination of Airborne Pathogens: A Study on aerosolized Mycobacterium tuberculosis and SARS-CoV-2 using ZeBox Technology.Rohan Narayan, Debosmita Kundu, Arindam Ghatak, Shashank Tripathi, Santanu Datta. Journal of Hospital Infection (2022). DOI:https://doi.org/10.1016/j.jhin.2022.07.021

  5. ORF6 protein of SARS-CoV-2 inhibits TRIM25 mediated RIG-I ubiquitination to mitigate type I IFN induction. Oyahida Khatun, Mansi Sharma, Rohan Narayan, Shashank Tripathi. bioRxiv ,6th May 2022 | DOI : https://doi.org/10.1101/2022.05.05.490850

  6. Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2. Mohammad Afsar, Rohan Narayan, Md Noor Akhtar, Deepakash Das, Huma Rahil, Santhosh Kambaiah Nagaraj, Sandeep M Eswarappa, Shashank Tripathi, Tanweer Hussain. eLife , 24th March 2022 | DOI : 10.7554/eLife.74877

  7. A natural broad-spectrum inhibitor of enveloped virus entry, effective against SARS-CoV-2 and Influenza A Virus in preclinical animal models. Rohan Narayan, Mansi Sharma, Rajesh Thangavel Yadav, Abhijith Biji, Oyahida Khatun, Raju S Rajmani, Pallavi Raj Sharma, Sharumathi Jeyashankar, Priya Rani, C. Durga Rao, Vijaya Satchidanandam, Saumitra Das, Rachit Agarwal, and Shashank Tripathi. bioRxiv 17th Feb 2022 | DOI : https://doi.org/10.1101/2022.02.16.480801

 

2021 :

 

  1. A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern.Shahbaz Ahmed, Mohammad Suhail Khan, Savitha Gayathri, Randhir Singh, Sahil Kumar, Unnatiben Rajeshbhai Patel, Sameer Kumar Malladi, Raju S. Rajmani, Petrus Jansen van Vuren, Shane Riddell, Sarah Goldie, Nidhi Girish, Poorvi Reddy, Aditya Upadhyaya, Suman Pandey, Samreen Siddiqui, Akansha Tyagi,Sujeet Jha, Rajesh Pandey, Oyahida Khatun,Rohan Narayan, Shashank Tripathi, Alexander J. McAuley, Nagendrakumar Balasubramanian Singanallur, Seshadri S. Vasan, Rajesh P. Ringe and Raghavan Varadarajan Front. Immunol., 09 December 2021
  2. Bioengineering Strategies for Developing Vaccines against Respiratory Viral Diseases.Shalini Iyer, Rajesh Yadav, Smriti Agarwal, Shashank Tripathi, Rachit Agarwal.Clinical microbiology reviews 17 November 2021
  3. Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative . Sameer Kumar Malladi, Unnatiben Rajeshbhai Patel, Raju S Rajmani, Randhir Singh, Suman Pandey, Sahil Kumar, Sara Khaleeq, Petrus Jansen van Vuren, Shane Riddell, Sarah Goldie, Savitha Gayathri, Debajyoti Chakraborty, Parismita Kalita, Ishika Pramanick, Nupur Agarwal, Poorvi Reddy, Nidhi Girish, Aditya Upadhyaya, Mohammad Suhail Khan, Kawkab Kanjo, Madhuraj Bhat, Shailendra Mani, Sankar Bhattacharyya, Samreen Siddiqui, Akansha Tyagi, Sujeet Jha, Rajesh Pandey, Shashank Tripathi, Somnath Dutta, Alexander J McAuley, Nagendrakumar Balasubramanian Singanallur, Seshadri S Vasan, Rajesh P Ringe, Raghavan Varadarajan. ACS Infectious Diseases 2021, 7, 8, 2546–2564;
  4. Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples.Abhijith Biji, Oyahida Khatun, Shachee Swaraj, Rohan Narayan, Raju Rajmani, Rahila Sardar, Deepshikha Satish, Simran Mehta, Hima Bindhu, Madhumol Jeevan, Deepak K Saini, Amit Singh, Dinesh Gupta, Shashank Tripathi  Lancet Ebiomedicine ,Volume 70, August 2021,103525 | DOI: https://doi.org/10.1016/j.ebiom.2021.103525
  5. Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagyLaura Martin-Sancho, Shashank Tripathi, Ariel Rodriguez-Frandsen, Lars Pache, Maite Sanchez-Aparicio, Michael J McGregor, Kelsey M Haas, Danielle L Swaney, Thong T Nguyen, João I Mamede, Christopher Churas, Dexter Pratt, Sara B Rosenthal, Laura Riva, Courtney Nguyen, Nish Beltran-Raygoza, Stephen Soonthornvacharin, Guojun Wang, David Jimenez-Morales, Paul D De Jesus, Hong M Moulton, David A Stein, Max W Chang, Chris Benner, Trey Ideker, Randy A Albrecht, Judd F Hultquist, Nevan J Krogan, Adolfo García-Sastre, Sumit K Chanda.Nature Microbiology(2021):1:15
  6. Innate Immune Subversion Strategies of Human Flaviviruses . Sumandeep kaur, Shashank Tripathi. Critical Reviews™ in Immunology | DOI : 10.1615/CritRevImmunol.2021039844

 

2020 :

  1. Live Visualization of Hemagglutinin Dynamics During Infection by Using a Novel Reporter Influenza A Virus Luiz Gustavo dos Anjos Borges†, Giuseppe Pisanelli†, Oyahida Khatun†, Adolfo García-Sastre and Shashank Tripathi* (†Equal Contribution) Viruses 2020, 12(6), 687;(Link)
  2. Intrinsic ADE: The dark side of antibody dependent enhancement during Dengue infection. Rohan Narayan, and Shashank Tripathi. Frontiers in Cellular and Infection Microbiology 10 (2020): 548.(Link)
  3. Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs. Tran, Vy, Mitchell P. Ledwith, Thiprampai Thamamongood, Christina A. Higgins, Shashank Tripathi, Max W. Chang, Christopher Benner et al. Nature microbiology (2020): 1-14. (link) 

2019 :

  1. The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response.Seifert LL, Si C, Saha D, Sadic M, de Vries M, Ballentine S, Briley A, Wang G, Valero-Jimenez AM, Mohamed A, Schaefer U, Moulton HM, García-Sastre A, Tripathi S, Rosenberg BR, Dittmann M. PLoS Pathog. 2019 Nov 4;15(11):e1007634.(link)
  2. Moving from Empirical to Rational Vaccine Design in the ‘Omics’ Era. Sharma M, Krammer F, García-Sastre A, Tripathi S. Vaccines (Basel). 2019 Aug 14;7(3) 

 

Pre IISc

 

2018 :

  1. Comparative flavivirus host protein interaction mapping reveals mechanisms of dengue and Zikavirus pathogenesis.Priya S. Shah, Nichole Link, Gwendolyn , Jang Phillip P. Sharp,Tongtong Zhu,Danielle L. Swaney, Jeffrey R. Johnson, John Von Dollen, Holly R. Ramage, Laura Satkamp, Billy Newton, Sebastian Aguirre, Ruth Hüttenhain, Marine J. Petit, Tierney Baum, Amanda Everitt, Orly Laufman, Michel Tassetto, Michael Shales, Erica Stevenson, Gabriel N. Iglesias, Leila Shokat, Shashank Tripathi et al, Nevan J. Krogan. Cell, 2018 Dec; 175(7):1931-45. (link)
  2. An Immunocompetent Mouse Model of Zika Virus Infection.Matthew J. Gorman, Elizabeth A. Caine, Konstantin Zaitsev, Matthew C. Begley, James Weger-Lucarelli, Melissa B. Uccellini, Shashank Tripathi et al, Adolfo Garcia-Sastre and Michael S. Diamond Cell Host & Microbe. 2018 May; 23(5):672-685.e6. (link
  3. Specific mutations in the PB2 protein of influenza A virus compensate for the lack of efficient IFN antagonism of the NS1 protein of bat influenza A-like viruses. Aydillo T, Ayllon J, Pavlisin A, Martinez-Romero C, Tripathi S, Mena I, Moreira-Soto A, Vicente-Santos A, Corrales-Aguilar E, Schwemmle M, García-Sastre A. Journal of virology. 2018 Jan: JVI-0202.(link)

2017 :

  1. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Bardina SV*, Bunduc P*, Tripathi S*, Duehr J*, Frere JJ, Brown JA, Nachbagauer R et al, Lim JK. Science. 2017 Apr; 356(6334):175-80. (* Equal Contribution) (link)
  2. Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.Sebastian Aguirre, Priya Luthra, Maria T. Sanchez-Aparicio, Ana M. Maestre, Jenish Patel, Francise Lamothe, Anthony C. Fredericks, Shashank Tripathi, et al, Ana Fernandez-Sesma. Nature microbiology. 2017 May; 2(5):17037. (link)
  3. A novel Zika virus mouse model reveals strain specific differences in the virus pathogenesis and host inflammatory immune response.Shashank Tripathi, Vinod Balasubramaniam, Julia A. Brown, Ignacio Mena, Alesha Grant et al, Adolfo García-Sastre. PLoS pathogens. 2017 Mar; 13(3):e1006258. (link)
  4. Systems-based Analysis of RIG-I-dependent Signaling Reveals that KHSRP Regulates Accessibility of Viral PAMPs for Innate Sensing. Stephen Soonthornvacharin, Ariel Rodriguez-Frandsen, Yingyao Zhou, Shashank Tripathi et al, Sunnie Yoh and Sumit K. Chanda. Nature microbiology. 2017 May; 2(5):17022. (link)

2016 :

  1. Antiviral innate immunity through the lens of systems biology. Tripathi S, Garcia-Sastre A. Virus Research. 2016 Jun; 218:10-7. (link)
  2. Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling. Grant A, Ponia SS, Tripathi S et al, García-Sastre A. Cell Host & Microbe. 2016 Jun; 19(6):882-90. (link)
  3. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S et al, Marazzi I. Immunity. 2016 Jan; 44(1):46-58. (link)
  4. Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins. Batra J*, Tripathi S*, Kumar A, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK. Scientific reports. 2016 Jan; 6:19063. (* Equal Contribution) (link)

2015 :

  1. Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding. Tripathi S*, Pohl MO*, Zhou Y, Rodriguez-Frandsen A et al, König R, Stertz S, García-Sastre A, Chanda SK. Cell host & microbe. 2015 Dec; 18(6):723-35. (* Equal Contribution) (link)
  2. Interplay between influenza A virus and host factors: targets for antiviral intervention. Tripathi S*, Batra J*, Lal SK. Archives of Virology. 2015 Aug; 160(8):1877-91. (* Equal Contribution) (link)
  3. Enhancement of the proapoptotic properties of newcastle disease virus promotes tumor remission in syngeneic murine cancer models. Cuadrado-Castano S, Ayllon J, Mansour M, de la Iglesia-Vicente J, Jordan S, Tripathi S, García-Sastre A, Villar E. Molecular Cancer Therapy. 2015 Mar; 14(5);1247-58. (link)

2011-2014 :

  1. Influenza A viral nucleoprotein interacts with cytoskeleton scaffolding protein α-actinin-4 for viral replication.Sharma S, Mayank AK, Nailwal H, Tripathi S et al, Lal SK. The FEBS journal. 2014 Jul; 281(13):2899-914. (link)
  2. Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin. Tripathi S, Batra J, Cao W, Sharma K et al, Lal SK. Cell death & disease. 2013 Mar; 4(3):e562 (link)
  3. Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation. Sharma K* , Tripathi S*, Ranjan P, Kumar P et al, Lal SK. (* Equal Contribution) PLoS One. 2011 Jun; 6(6):e20215 (link)
  4. Infection of lung epithelial cells with pandemic 2009 A(H1N1) influenza viruses reveals isolate-specific differences in infectivity and host cellular responses. Patel JR, Vora KP, Tripathi S, Zeng H, Tumpey TM, Katz JM, Sambhara S, Gangappa S. Viral Immunology. 2011 Apr; 24(2):89-99. (link)