e-mail

office.cidr@iisc.ac.in

Publication

2026:

  1. FNDR-11124, a broad-spectrum small molecule inhibitor of viral RNA polymerase, restricts replication of SARS-CoV-2 and Influenza virus in vitro and in vivo. Gudepalya Renukaiah Rudramurthy, Chandra S. Gudla, Rajappa Harisha, Vignesh Selvam, Likhitha K. Vijaykumar, Varun Kailaje, Chakenahalli Naveenkumar, Kumaraswamy Bharathkumar, Siva Shanmugam, Rohan Narayan, Aditi Kanoji, Shashank Tripathi, Ankush Roy, Vidya M. Prasad, Tanvi Sharad, Shwetha Shivaprasad, Ravinder R. Kondreddi, Mayas Singh, Radha K. Shandil, Shridhar Narayanan. Antiviral Research, Link
  2. A novel molecule inhibits SARS-CoV-2 RBD binding to the ACE2 receptor, blocks viral entry and exhibits antiviral activity in a murine model. Sanketkumar Nehul, Santhosh K. Nagaraj, Rohan Narayan, Ankur Singh, Mandar Bhutkar, Vishakha Singh, Ruchi Rani, Harry Kaur, Ashwani Kumar Sharma, Pravindra Kumar, Gaurav Kumar Sharma, Shashank Tripathi, Shailly Tomar. Archives of Virology, Link

2025:

  1. Anti-interferon armamentarium of human coronaviruses. Oyahida Khatun, Sumandeep Kaur, and Shashank Tripathi. Cellular and Molecular Life Sciences, Link
  2. Differential modulation of Interferon and Cell Death Responses Define Human vs Avian Influenza A Virus Strain-Specific Virulence and guide Combination Therapy. Mansi Sharma, Abinaya Kaliappan, Dharmesh Bisoriya, Rajesh T. Yadav, Rohan Narayan, Shachee Swaraj, Guojun Wang, Adolfo García-Sastre, Shashank Tripathi. bioRxiv, Link
  3. Gut infection and dysbiosis are hallmarks of severe SARS-CoV-2 variants. Santhosh K Nagaraj, Christy M Joy, Rishad Shiraz, Rohan Narayan, Sumandeep Kaur, Oyahida Khatun, Sagar Dubey, James Ng, Nischay Mishra, Shashank Tripathi. npj Viruses, Link
  4. An Oral Combination therapy against SARS-CoV-2 based on Synergistic Action of Auranofin and Remdesivir, Oyahida Khatun, Rohan Narayan, Santhosh K Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi, bioRxiv, Link
  5. Deubiquitinase inhibitors: Targeting SARS‐CoV‐2 papain‐like protease with antiviral efficacy in a murine model, Shweta Choudhary, Sanketkumar Nehul, Santhosh K Nagaraj, Rohan Narayan, Shalja Verma, Swati Sharma, Annu Kumari, Ruchi Rani, Ankita Saha, Debabrata Sircar, Abinaya Kaliappan, Shashank Tripathi, Gaurav Kumar Sharma, Pravindra Kumar, Shailly Tomar. The FEBS Journal, Link

2024:

  1. Bat RNA viruses employ viral RHIMs orchestrating species-specific cell death programs linked to Z-RNA sensing and ZBP1-RIPK3 signaling.Sanchita Mishra, Disha Jain, Ayushi Amin Dey, Sahana Nagaraja, Mansi Srivastava, Oyahida Khatun, Keerthana Balamurugan, Micky Anand, Avinash Karkada Ashok, Shashank Tripathi, Mahipal Ganji, Sannula Kesavardhana. iScience, Link
  2. Scalable bioprocess for the high-yield production of SARS-CoV-2 trimeric spike protein-based immunogen (IMT-CVAX) using suspension CHO cells. Sneha Singh, B. Vikram Kumar, Jitender, a, Pranaya M. Mishra, Geetika Verma, Suvechchha Pandit, Sahil Kumar, Reetesh Kumar, Rajesh P. Ringe, Shashank Tripathi, Nimesh Gupta and Ravi P.N. Mishra. Process Biochemistry, Link
  3. Mammalian cell expressed recombinant trimeric spike protein is a potent vaccine antigen and confers near-complete protection against SARS-CoV-2 infection in Hamster. B Vikram Kumar, Sneha Singh, Geetika Verma, Reetesh Kumar, Pranaya M Mishra, Sahil Kumar, Santhosh K Nagaraj, Joydeep  Nag, Christy M Joy, Bhushan Nikam, Dharmendra Singh, Nidhi Kalidas, Shubham Singh, Ashwani K Bhardwaj, Dhananjay S Mankotia, Rajesh P Ringe, Nimesh Gupta, Shashank Tripathi, Ravi PN Mishra. Vaccine, Link
  4. Interference without interferon: interferon-independent induction of interferon-stimulated genes and its role in cellular innate immunity Shachee Swaraj, Shashank Tripathi. mBio, Link

2023:

  1. Mucosal SARS-CoV-2 vaccination of rodents elicits superior systemic T central memory function and cross-neutralising antibodies against variants of concern.Aled O’Neill, Chinmay Kumar Mantri, Chee Wah Tan, Wilfried AA Saron, Santhosh K Nagaraj, Monica Palanichamy Kala, Christy M. Joy, Abhay PS Rathore, Shashank Tripathi, Lin-Fa Wang, Ashley L St John. Ebiomedicine, Link
  2. SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction Oyahida Khatun, Mansi Sharma, Rohan Narayan, Shashank Tripathi. Cellular and Molecular Life Sciences, Link
  3. Picolinic acid is a broad-spectrum inhibitor of enveloped virus entry that restricts SARS-CoV-2 and influenza A virus in vivo. Rohan Narayan, Mansi Sharma, Rajesh Yadav, Abhijith Biji, Oyahida Khatun, Sumandeep Kaur, Aditi Kanojia, Christy Margrat Joy, Raju Rajmani, Pallavi Raj Sharma, Sharumathi Jeyasankar, Priya Rani, Radha Krishan Shandil, Shridhar Narayanan, Durga Chilakalapudi Rao, Vijaya Satchidanandam, Saumitra Das, Rachit Agarwal, Shashank Tripathi. Cell Reports Medicine, Link
  4. A broadly protective CHO cell expressed recombinant spike protein subunit based vaccine (IMT-CVAX) against SARS-CoV-2.Bhusarapu Vikram Kumar, Sneha Singh, Geetika Verma, Reetesh Kumar, Pranaya M Mishra, Sahil Kumar, Santhosh K Nagaraj, Joydeep Nag, Christy M Joy, Bhushan Nikam, Dharmendra Singh, Nidhi Kalidas, Shubham Singh, Ashwani K Bhardwaj, Dhananjay S Mankotia, Rajesh P Ringe, Nimesh Gupta, Shashank Tripathi, Ravi PN Mishra. bioRxiv, Link
  5. Human antigen R differentially modulates the translation of SARS-CoV-2 genomic and sub-genomic RNAs, Harsha Raheja, Risabh Sahu, Trinath Ghosh, Priya Rani, Biju George, Shashank Tripathi, Saumitra Das. bioRxiv, Link
  6. Enhanced recombination among Omicron subvariants of SARS‐CoV‐2 contributes to viral immune escape. Rishad Shiraz, Shashank Tripathi. Medical Virology, Link
  7. Ubiquitin-Mediated Regulation of Autophagy During Viral Infection. Joydeep Nag, Janvi Patel, Shashank Tripathi. Current Clinical Microbiology Reports, Link
  8. Human antigen R differentially modulates the translation of SARS-CoV-2 genomic and sub-genomic RNAs, Harsha Raheja, Risabh Sahu, Trinath Ghosh, Priya Rani, Biju George, Shashank Tripathi, Saumitra Das. bioRxiv, Link
  9. A broadly protective CHO cell expressed recombinant spike protein subunit based vaccine (IMT-CVAX) against SARS-CoV-2.Bhusarapu Vikram Kumar, Sneha Singh, Geetika Verma, Reetesh Kumar, Pranaya M Mishra, Sahil Kumar, Santhosh K Nagaraj, Joydeep Nag, Christy M Joy, Bhushan Nikam, Dharmendra Singh, Nidhi Kalidas, Shubham Singh, Ashwani K Bhardwaj, Dhananjay S Mankotia, Rajesh P Ringe, Nimesh Gupta, Shashank Tripathi, Ravi PN Mishra. bioRxiv, Link
  10. Ubiquitin-Mediated Regulation of Autophagy During Viral Infection. Joydeep Nag, Janvi Patel, Shashank Tripathi. bioRxiv, Link
  11. Enhanced recombination among Omicron subvariants of SARS‐CoV‐2 contributes to viral immune escape. Rishad Shiraz, Shashank Tripathi. Medical Virology, Link

2022:

  1. Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans. Christian V Forst, Laura Martin-Sancho, Shashank Tripathi, Guojun Wang, Luiz Gustavo Dos Anjos Borges, Minghui Wang, Adam Geber, Lauren Lashua, Tao Ding, Xianxiao Zhou, Chalise E Carter, Giorgi Metreveli, Ariel Rodriguez-Frandsen, Matthew D Urbanowski, Kris M White, David A Stein, Hong Moulton, Sumit K Chanda, Lars Pache, Megan L Shaw, Ted M Ross, Elodie Ghedin, Adolfo García-Sastre, Bin Zhang. Science Advances, Link

  2. Flavivirus–Host Interaction Landscape Visualized through Genome-Wide CRISPR Screens. Aditi Kanojia, Mansi Sharma, Rishad Shiraz, Shashank Tripathi. Viruses, Link

  3. Enhanced Recombination Among SARS-CoV-2 Omicron Variants Contribute To Viral Immune Escape. Rishad Shiraz, Shashank Tripathi. bioRxiv, Link

  4. Efficient Elimination of Airborne Pathogens: A Study on aerosolized Mycobacterium tuberculosis and SARS-CoV-2 using ZeBox Technology.Rohan Narayan, Debosmita Kundu, Arindam Ghatak, Shashank Tripathi, Santanu Datta. Journal of Hospital Infection, Link

  5. ORF6 protein of SARS-CoV-2 inhibits TRIM25 mediated RIG-I ubiquitination to mitigate type I IFN induction. Oyahida Khatun, Mansi Sharma, Rohan Narayan, Shashank Tripathi. bioRxiv, Link

  6. Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2. Mohammad Afsar, Rohan Narayan, Md Noor Akhtar, Deepakash Das, Huma Rahil, Santhosh K Nagaraj, Sandeep M Eswarappa, Shashank Tripathi, Tanweer Hussain. eLife, Link

  7. A natural broad-spectrum inhibitor of enveloped virus entry, effective against SARS-CoV-2 and Influenza A Virus in preclinical animal models. Rohan Narayan, Mansi Sharma, Rajesh Thangavel Yadav, Abhijith Biji, Oyahida Khatun, Raju S Rajmani, Pallavi Raj Sharma, Sharumathi Jeyashankar, Priya Rani, C. Durga Rao, Vijaya Satchidanandam, Saumitra Das, Rachit Agarwal, and Shashank Tripathi. bioRxiv, Link

2021 :

  1. A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern.Shahbaz Ahmed, Mohammad Suhail Khan, Savitha Gayathri, Randhir Singh, Sahil Kumar, Unnatiben Rajeshbhai Patel, Sameer Kumar Malladi, Raju S. Rajmani, Petrus Jansen van Vuren, Shane Riddell, Sarah Goldie, Nidhi Girish, Poorvi Reddy, Aditya Upadhyaya, Suman Pandey, Samreen Siddiqui, Akansha Tyagi,Sujeet Jha, Rajesh Pandey, Oyahida Khatun, Rohan Narayan, Shashank Tripathi, Alexander J. McAuley, Nagendrakumar Balasubramanian Singanallur, Seshadri S. Vasan, Rajesh P. Ringe and Raghavan Varadarajan Front. Immunol., Link
  2. Bioengineering Strategies for Developing Vaccines against Respiratory Viral Diseases. Shalini Iyer*, Rajesh Yadav*, Smriti Agarwal*, Shashank Tripathi, Rachit Agarwal. (* Equal Contribution) Clinical microbiology reviews, Link
  3. Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative. Sameer Kumar Malladi, Unnatiben Rajeshbhai Patel, Raju S Rajmani, Randhir Singh, Suman Pandey, Sahil Kumar, Sara Khaleeq, Petrus Jansen van Vuren, Shane Riddell, Sarah Goldie, Savitha Gayathri, Debajyoti Chakraborty, Parismita Kalita, Ishika Pramanick, Nupur Agarwal, Poorvi Reddy, Nidhi Girish, Aditya Upadhyaya, Mohammad Suhail Khan, Kawkab Kanjo, Madhuraj Bhat, Shailendra Mani, Sankar Bhattacharyya, Samreen Siddiqui, Akansha Tyagi, Sujeet Jha, Rajesh Pandey, Shashank Tripathi, Somnath Dutta, Alexander J McAuley, Nagendrakumar Balasubramanian Singanallur, Seshadri S Vasan, Rajesh P Ringe, Raghavan Varadarajan. ACS Infectious Diseases, Link
  4. Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples.Abhijith Biji, Oyahida Khatun, Shachee Swaraj, Rohan Narayan, Raju Rajmani, Rahila Sardar, Deepshikha Satish, Simran Mehta, Hima Bindhu, Madhumol Jeevan, Deepak K Saini, Amit Singh, Dinesh Gupta, Shashank Tripathi. Lancet Ebiomedicine, Link
  5. Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagyLaura Martin-Sancho, Shashank Tripathi, Ariel Rodriguez-Frandsen, Lars Pache, Maite Sanchez-Aparicio, Michael J McGregor, Kelsey M Haas, Danielle L Swaney, Thong T Nguyen, João I Mamede, Christopher Churas, Dexter Pratt, Sara B Rosenthal, Laura Riva, Courtney Nguyen, Nish Beltran-Raygoza, Stephen Soonthornvacharin, Guojun Wang, David Jimenez-Morales, Paul D De Jesus, Hong M Moulton, David A Stein, Max W Chang, Chris Benner, Trey Ideker, Randy A Albrecht, Judd F Hultquist, Nevan J Krogan, Adolfo García-Sastre, Sumit K Chanda. Nature Microbiology, Link
  6. Innate Immune Subversion Strategies of Human Flaviviruses . Sumandeep kaur, Shashank Tripathi. Critical Reviews™ in Immunology, Link

2020 :

  1. Live Visualization of Hemagglutinin Dynamics During Infection by Using a Novel Reporter Influenza A Virus Luiz Gustavo dos Anjos Borges†, Giuseppe Pisanelli†, Oyahida Khatun†, Adolfo García-Sastre and Shashank Tripathi* (†Equal Contribution) Viruses, Link
  2. Intrinsic ADE: The dark side of antibody dependent enhancement during Dengue infection. Rohan Narayan, and Shashank Tripathi. Frontiers in Cellular and Infection Microbiology, Link
  3. Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs. Tran, Vy, Mitchell P. Ledwith, Thiprampai Thamamongood, Christina A. Higgins, Shashank Tripathi, Max W. Chang, Christopher Benner et al. Nature microbiology Link

2019 :

  1. The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response.Seifert LL, Si C, Saha D, Sadic M, de Vries M, Ballentine S, Briley A, Wang G, Valero-Jimenez AM, Mohamed A, Schaefer U, Moulton HM, García-Sastre A, Tripathi S, Rosenberg BR, Dittmann M. PLoS Pathogen Link
  2. Moving from Empirical to Rational Vaccine Design in the ‘Omics’ Era. Mansi Sharma, Florian Krammer, Adolfo García-Sastre, Shashank Tripathi. Vaccines (Basel), Link

Pre IISc

2018 :

  1. Comparative flavivirus host protein interaction mapping reveals mechanisms of dengue and Zikavirus pathogenesis. Priya S. Shah, Nichole Link, Gwendolyn , Jang Phillip P. Sharp,Tongtong Zhu,Danielle L. Swaney, Jeffrey R. Johnson, John Von Dollen, Holly R. Ramage, Laura Satkamp, Billy Newton, Sebastian Aguirre, Ruth Hüttenhain, Marine J. Petit, Tierney Baum, Amanda Everitt, Orly Laufman, Michel Tassetto, Michael Shales, Erica Stevenson, Gabriel N. Iglesias, Leila Shokat, Shashank Tripathi et al, Nevan J. Krogan. Cell, Link
  2. An Immunocompetent Mouse Model of Zika Virus Infection.Matthew J. Gorman, Elizabeth A. Caine, Konstantin Zaitsev, Matthew C. Begley, James Weger-Lucarelli, Melissa B. Uccellini, Shashank Tripathi et al, Adolfo Garcia-Sastre and Michael S. Diamond Cell Host & Microbe, Link
  3. Specific mutations in the PB2 protein of influenza A virus compensate for the lack of efficient IFN antagonism of the NS1 protein of bat influenza A-like viruses. Aydillo T, Ayllon J, Pavlisin A, Martinez-Romero C, Tripathi S, Mena I, Moreira-Soto A, Vicente-Santos A, Corrales-Aguilar E, Schwemmle M, García-Sastre A. Journal of virology, Link

2017 :

  1. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Bardina SV*, Bunduc P*, Tripathi S*, Duehr J*, Frere JJ, Brown JA, Nachbagauer R et al, Lim JK. (* Equal Contribution) Science,  Link
  2. Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection. Sebastian Aguirre, Priya Luthra, Maria T. Sanchez-Aparicio, Ana M. Maestre, Jenish Patel, Francise Lamothe, Anthony C. Fredericks, Shashank Tripathi, et al, Ana Fernandez-Sesma. Nature microbiology. Link
  3. A novel Zika virus mouse model reveals strain specific differences in the virus pathogenesis and host inflammatory immune response.Shashank Tripathi, Vinod Balasubramaniam, Julia A. Brown, Ignacio Mena, Alesha Grant et al, Adolfo García-Sastre. PLoS pathogens, Link
  4. Systems-based Analysis of RIG-I-dependent Signaling Reveals that KHSRP Regulates Accessibility of Viral PAMPs for Innate Sensing. Stephen Soonthornvacharin, Ariel Rodriguez-Frandsen, Yingyao Zhou, Shashank Tripathi et al, Sunnie Yoh and Sumit K. Chanda. Nature microbiology, Link

2016 :

  1. Antiviral innate immunity through the lens of systems biology. Tripathi S, Garcia-Sastre A. Virus Research, Link
  2. Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling. Grant A, Ponia SS, Tripathi S et al, García-Sastre A. Cell Host & Microbe Link
  3. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S et al, Marazzi I. Immunity, Link
  4. Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins. Batra J*, Tripathi S*, Kumar A, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK.(*Equal Contribution) Scientific reports  Link

2015 :

  1. Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding. Tripathi S*, Pohl MO*, Zhou Y, Rodriguez-Frandsen A et al, König R, Stertz S, García-Sastre A, Chanda SK. (*Equal Contribution) Cell host & microbe Link
  2. Interplay between influenza A virus and host factors: targets for antiviral intervention. Tripathi S*, Batra J*, Lal SK. (*Equal Contribution) Archives of Virology,  Link
  3. Enhancement of the proapoptotic properties of newcastle disease virus promotes tumor remission in syngeneic murine cancer models. Cuadrado-Castano S, Ayllon J, Mansour M, de la Iglesia-Vicente J, Jordan S, Tripathi S, García-Sastre A, Villar E. Molecular Cancer Therapy, Link

2011-2014 :

  1. Influenza A viral nucleoprotein interacts with cytoskeleton scaffolding protein α-actinin-4 for viral replication.Sharma S, Mayank AK, Nailwal H, Tripathi S et al, Lal SK. The FEBS journal Link
  2. Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein Clusterin. Tripathi S, Batra J, Cao W, Sharma K et al, Lal SK. Cell death & disease, Link
  3. Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation. Sharma K* , Tripathi S*, Ranjan P, Kumar P et al, Lal SK. (* Equal Contribution) PLoS One, Link
  4. Infection of lung epithelial cells with pandemic 2009 A(H1N1) influenza viruses reveals isolate-specific differences in infectivity and host cellular responses. Patel JR, Vora KP, Tripathi S, Zeng H, Tumpey TM, Katz JM, Sambhara S, Gangappa S. Viral Immunology. Link