Principal Investigators
Dr. Amit Singh
Professor
Our research aims to understand the fundamental mechanisms involved in chronic human infections. We are focusing on dissecting how bioenergetic changes in the host and pathogens’ physiology control Mycobacterium tuberculosis’s virulence and drug tolerance. We integrate basic and clinical technologies to study mechanisms regarding latency and reactivation of human immunodeficiency virus (HIV). Altogether, our efforts are to transform basic findings into discoveries for therapeutic benefits.
Research Theme
- Fundamental mechanism underlying persistence and phenotypic antimicrobial (AMR) in Mycobacterium tuberculosis.
- Host directed thearphy against TB, HIV, and HIV-TB coinfection
Dr. Shashank Tripathi
Associate Professor
Our group studies virus-host interactions of emerging human RNA viruses, including influenza, SARS- CoV-2, and Flaviviruses. We strive to translate this knowldegd to develop broad -spectrum antivirals and vaccines. Our expertise is in multi-omics analysis of virus-host interactions, viral reverse genetics, and small-animal models of viral pathogenesis.
Research Theme
- Virus -Host Interactions (influenza Flavivirus, Human Corona Viruses)
- Antiviral and Vaccines
- Antiviral Innate Immunity
Dr. Vidya Mangala Prasad
Assistant Professor
Our lab at the Indian Institute of Science (IISc-Bangalore) focuses on high-resolution structural analysis of human disease-causing viruses, their infection machinery, and mechanisms of cellular entry across membranes using cryo-electron tomography, subtomogram averaging, single-particle cryo-electron microscopy, and other biophysical and molecular methods.
Research Theme
- High-resolution structural studies on pathogenic viruses, antigenic determinants, and modes of cellular infection.
- We primarily use cryo-electron microscopy (cryo-EM) methods, such as cryo-electron tomography, subtomogram averaging, and single-particle cryo-EM, along with other molecular and biophysical tools.
Dr. William Surin
Principal Research Scientist
Our research focuses on advancing the understanding of thrombosis, platelet biology, and chronic respiratory diseases through innovative experimental approaches. We investigate platelet signaling pathways involved in intravascular thrombosis and evaluate antithrombotic strategies to identify novel therapeutic interventions for thrombotic disorders. In parallel, our work aims to elucidate the pathogenesis of Inflammatory respiratory diseases like Chronic Obstructive Pulmonary Disease (COPD) by developing robust animal models and advanced in vitro test systems, enabling the identification of key molecular targets and signaling pathways for effective therapeutic development.
Dr. Sujay Halkur Shankar
Assistant professor
We study the immunobiology of lung injury and repair to understand how dysregulated inflammation drives chronic respiratory disease. We investigate immune pathways that govern host–microbial interactions, tissue repair, fibrosis, and the development of chronic respiratory diseases. Our current focus is on studying the immune milieu of post-tubercular lung disease and elucidating the immunopathogenesis of chronic pulmonary aspergillosis. Our goal is to actively translate findings to patient care, to help predict, prevent, and treat chronic respiratory diseases.
Research Themes
- Immune dysfunction in chronic respiratory disease (In post-tubercular lung disease and interstitial lung disease)
- Host-pathogen interaction (With focus on fungal and mycobacterial infections)